Around 1675 he married Mary Isham (1660 Bermuda Hundred, James River, Henrico County, Virginia–25 December 1735 Turkey Island, Henrico County, Virginia), whose father, Henry Isham (c. 1628 Pytchley, Northamptonshire–c. 1676 Bermuda Hundred, James River, Henrico County, Virginia), was from a gentry family in Northamptonshire. After arriving in Virginia, Henry had married in 1659, a wealthy widow, Katherina Banks Royall (c. 1630 Canterbury, Kent–aft. 1 December 1686 Henrico County, Virginia).