Pierson, who was born and raised in Brooklyn, New York originally played the role of Marko in the original Broadway production of Stalag 17, and was tapped by Director Billy Wilder for the role in the 1953 motion picture production. Other Broadway appearances included in High Button Shoes, Make Mine Manhattan, Reuben, Reuben, and in a national touring company of The Odd Couple. Pierson, who was well recognized by his distinctive, raspy delivery, also appeared in the Off Broadway production Smile, Smile, Smile. After Wilder brought him to Hollywood, he appeared in films such as Operation Madball and Fun with Dick and Jane (1977).