Hampden appeared in a few silent films, but did not really begin his film career in earnest until 1939, when he played the Archbishop in The Hunchback of Notre Dame, starring Charles Laughton as Quasimodo. This was Hampden's first sound film; he was 60 at the time he made it. Several other roles followed—Jarvis Langdon in the 1944 film The Adventures of Mark Twain among them, but all were supporting character roles, not the lead roles that Hampden played onstage. He was the master of ceremonies at the Sarah Siddons Awards in All About Eve (1950), and he played the father of Humphrey Bogart and william Holden in Billy Wilder's 1954 comedy Sabrina. These last two films are arguably those for which Hampden is most well known to modern audiences. He also played long-bearded patriarchs in the Biblical epics The Silver Chalice (1954, as Joseph of Arimathea) and The Prodigal (1955).