Born in New York City to Sally Landsburg, a Psychologist and author, and Alan Landsburg. Landsburg made her acting debut in the 1978 disco movie Thank God It's Friday. In 1980 she took over the role of Libby in Neil Simon's I Ought to Be in Pictures. In 1982, she appeared in the NBC television series Fame. During the series run, Landsburg wrote and directed one episode of the series. Shortly after Landsburg left the show in 1987, she co-starred in two different comedy TV series, which practically ran at the same time. The first, You Again?, starred Jack Klugman, and lasted for one season. From the creators of Cheers, next came the Bess Armstrong series All Is Forgiven, which NBC cancelled after nine episodes. Despite its limited engagement, the series was rebroadcast on the A&E network through 1989, where it gained a broader audience.