From 2003 to 2005, Vaughn was regular cast member on the UPN/The CW sitcom All of Us. In 2007, she had supporting role in the Tyler Perry's comedy-drama film Daddy's Little Girls opposite Gabrielle Union, and later had the regular role on another Perry's production, Meet the Browns (2009-2011). She also has appeared and produced number of low-profile movies in later years. She is owned production company called Nina Holiday Entertainment, that produced films such as Sugar Mommas, A Cross to Bear and Girlfriends' Getaway. In 2016, Vaughn has made her directing debut with comedy film #DigitalLivesMatter.