Balsam married actor George Clooney in Las Vegas in 1989; they were divorced in 1993. Clooney stated, "I probably – definitely – wasn't someone who should have been married at that point." Clooney told Vanity Fair, "I just don't feel like I gave Talia a fair shot." Since 1998 Balsam has been married to John Slattery with whom she has a son, Harry Slattery. They married at the county of Kauai. Together, they played husband and wife Roger and Mona Sterling in Mad Men.