Since the 1990s, Blakeslee has been voice acting in animation, video games, and theme parks. She is best known as the voice of Timmy Turner's fairy godmother, Wanda, on the animated TV series, The Fairly OddParents (2001–17); The Jimmy Timmy Power Hour trilogy (a crossover with the Jimmy Neutron franchise (2004)); and the live-action TV films, A Fairly Odd Movie: Grow Up, Timmy Turner! (2011); A Fairly Odd Christmas (2012); and A Fairly Odd Summer (2014). She also voiced other characters on the same show, including Timmy's mother, Mrs. Turner, and Anti-Wanda.