Tuohy married his wife, Leigh Anne, in the mid-1980s and the couple have two children together, and are also the adoptive parents of Michael Oher. In addition to Michael Oher, the Tuohys are parents to daughter Collins Tuohy (December 1986), who was a state champion at the pole vault and Cheerleader, and son Sean Tuohy Jr. (July 1993), who played guard for the Loyola Greyhounds. Tuohy and his wife live in Memphis, Tennessee.