Her other television credits include The Bill, Cold Feet, Plebs, Coupling, After You've Gone and M.I.T.: Murder Investigation Team, in which she played the lead role of DI Vivien Friend. She described the role of Friend as "quite an unusual departure for me...I've done quite a bit of comedy and I've played characters who are light-hearted and characters who are tarts with hearts. In M.I.T. there is no tart or heart!" In order to research the part, Spiro spent time with a female Detective Inspector with the real-life Murder Investigation Team. From 9 August 2010, Spiro starred in the BBC comedy Grandma's House. She plays the part of Simon Amstell's aunt Liz. In 2012 she also appeared in the SkyArts comedy series 'Psychobitches where she played various female icons including Audrey Hepburn, Elizabeth Taylor, Marilyn Monroe and Mary Whitehouse.