From the beginning, despite the risk to his livelihood, he defended runaway slaves and those tried for assisting them. He became particularly devoted to the abolition of slavery from the death of his first wife, Katherine Jane Garmiss, in 1835, shortly after their March 1834 wedding, an event which was a spiritual reawakening for him. He worked initially with the American Sunday School Union. At a time when public opinion in Cincinnati was dominated by Southern Business connections, Chase, influenced by local events, including the attack on the press of James G. Birney during the Cincinnati Riots of 1836, associated himself with the anti-slavery movement. Chase was also a member of the literary Semi-Colon Club; its members included Harriet Beecher Stowe and Calvin Stowe. Chase became the leader of the political reformers, as opposed to the Garrisonian abolitionist movement.