Prior to studying art and film, Rist studied theoretical physics in Vienna for one semester. From 1982 to 1986 Rist studied commercial art, illustration, and photography at the University of Applied Arts Vienna in Vienna. She later studied video at the School of Design (Schule für Gestaltung) in Basel, Switzerland. From 1988 through 1994, she was member of the music band and performance group Les Reines prochaines. In 1997, her work was first featured in the Venice Biennial, where she was awarded the Premio 2000 Prize. From 2002 to 2003, she was invited by Professor Paul McCarthy to teach at UCLA as a visiting faculty member. From Summer 2012 through to Summer 2013, Rist spent a sabbatical in Somerset.