In 2001, Reiser played a dramatic role as a man desperate to locate his biological mother, after learning he has a serious illness, in the British TV film My Beautiful Son. In 2002, Reiser made a guest appearance as himself on Larry David's HBO sitcom, Curb Your Enthusiasm. In the TV comedy film Atlanta (2007), Reiser appears as one half of a couple who, after meeting at a funeral, are unable to stay away from each other. In 2010, Reiser collaborated with the singer Julia Fordham to create a CD album titled Unusual Suspects, which includes the song "UnSung Hero", dedicated to American Soldiers serving in Afghanistan. The two embarked on an acoustic tour after its release. Reiser also co-wrote the song, "No There There" with Melissa Manchester for her 2015 album, You Gotta Love the Life. Early in his career, Reiser was the opening act for Manchester, she warned him that music audiences can be rough on comedians and that the last Comedian that opened for her, left the stage in tears. Reiser reflects about this warning and on how he then bombed at the Concord Hotel. The story is detailed the chapter, "Don't Worry if They Suck", by Paul Reiser, in I Killed: True Stories of the Road from America's Top Comics (2010), By Ritch Shydner, Mark Schiff.