From the beginning of her career, Khan has created diverse images that work to subvert television stereotypes. She is best known for creating the ABC sitcoms Don't Trust the B---- in Apartment 23 and Fresh Off the Boat. Fresh Off the Boat, based on restauranteur Eddie Huang's memoir, made television history by centering the experiences of a Taiwanese-American family in Florida. One critic commented on its additional significance that, "It was the first show to feature an Asian American cast since All American Girl in 1994. In at least one show, Asian-Americans would not be desexualized, hypersexualized, caricatured or stereotyped." A lesbian herself, Fresh Off the Boat routinely features queer themes: Eddie’s mom, Jessica (Constance Woo), regularly visits the local lesbian bar, The Denim Turtle. Eddie's love interest, Nicole, struggles to come out to her father and family.