Melissa Mathison was born on June 3, 1950 in Los Angeles, California, one of five siblings. Her father, Richard Randolph Mathison, was the Los Angeles bureau chief of Newsweek. Her mother was Margaret Jean (née Kieffer) Mathison, a food Writer and convenience-foods Entrepreneur. After graduating from Providence High School in 1968, Mathison attended the University of California, Berkeley. Her family was friendly with Francis Ford Coppola, whose children were babysat by Mathison. Coppola offered her a job as his assistant on The Godfather Part II, an opportunity for which she left her studies at UC Berkeley.