Indelicato was born in Philadelphia, the son of Lynn and Mark Indelicato, Sr. He is of three quarters Italian and one quarter Puerto Rican descent. He was trained at The Actors Center in that city, and is a student at Dupree School of Music in Linwood, New Jersey. He began acting at age eight at Philadelphia's Walnut Street Theater, and has appeared in national television commercials, the CBS television series Hack, Chappelle's Show, and was a regular cast member of Ugly Betty on ABC until the series ended in 2010. He also attended the Professional Performing Arts School, before moving back to Los Angeles. He is attending New York University’s Gallatin School of Individualized Study.