In 1956, while she was appearing in Anniversary Waltz, Lord caught the attention of Danny Thomas who asked her to replace Jean Hagen as his television wife on Make Room for Daddy. Hagen had played Thomas' wife since the series' inception, but she was written out of the script in 1956. Lord accepted the role and joined the cast of the show, now called The Danny Thomas Show. She played the role until the show was cancelled in 1964. In 1970, Lord and Thomas, along with several other original supporting actors, returned to television with Make Room for Granddaddy. The show lasted just one season.