Throughout the 2000s, she guest-starred in episodes of The Dead Zone, The Twilight Zone, and Blade: The Series, among others. Smith was also a recurring character in the Showtime drama series The L Word, playing sous chef Lara Perkins. In 2005, Smith filmed the sexually explicit movie Lie with Me, where she played the character of Leila. The same year, she was cast in the 2006 romance film The Last Kiss.