In 1995, van Straten had her first regular role in a television series, as Maggie Reynolds on The Crew. Other recurring roles include Geneva Renault in Total Security, Candy Cooper in That's Life, Rebecca Colfax in Dirty Sexy Money, and Belinda Slypich in Hidden Hills. Perhaps her best known film role was in Dancing at the Blue Iguana in 2000. Van Straten played a porn star appearing as the featured act at a Los Angeles strip club and performed an extended nude dance. In 2001, she starred in the award-winning short film Room 302, and in 2004 she had a minor role in the film 50 First Dates, which starred Adam Sandler. In the animated series Justice League, she supplied the voice of the superhero Mera.