Issova has appeared in many films, TV serials and plays. Her notable film appearances are in Indian Summer (1995), The Mists of Avalon (2001), Frank Herbert's Children of Dune (2003), and Surviving Life (2010). She also played a short role in the movie The Chronicles of Narnia: Prince Caspian (2008). In 2000, for the movie Angel Exit she shaved her head completely onscreen and went bald. She was nominated for Czech Lion Awards for best Actress in 2000 for the same movie. Her noteworthy TV appearances are in No Problem (1997), Joan of Arc (1999), Anne Frank: The Whole Story (2001), and Operace Silver A (2007). Her stage credits include in Shots in Broadway and Private Eye.