Hamilton appeared in more than 60 television series and television films throughout her career. In 1960, she guest-starred in an episode of The Twilight Zone called "The Big Tall Wish." In 1963 and 1964, she played a high-school librarian on two episodes of the popular series My Three Sons. She also became one of the first black actresses to appear on the soap opera Days of Our Lives. Other roles included guest spots on The Thin Man, General Hospital, Sanford and Son, Good Times, The Jeffersons, In the Heat of the Night, All In The Family, and Law & Order. She portrayed Songi in "Final Mission" a 1990 episode of Star Trek: The Next Generation. Her last television credit was a 2008 episode of the ABC series Private Practice.