Her early film career included roles in The Incubus (1982), Spasms (1983), Morning Man (1986) and Bates Motel (1987). In 1987 she appeared in the film Obsessed and was nominated for the 1989 Genie Award for Best Performance by an Actress in a Leading Role. Keane also played the leading female role in the film Distant Thunder (1988) and appeared in the superhero film Steel (1997). She co-hosted What Will They Think of Next?, and appeared on episodes of such television series as Star Trek: The Next Generation, Matlock and Beverly Hills, 90210.