Meisle made her San Francisco Opera debut as Amneris in Aida on October 1, 1926. She sang with the company in the years 1926-1927, 1929, 1932-1933, 1935-36, performing the roles of Azucena in Il trovatore, Brangäne in Tristan und Isolde, The Witch in Hansel und Gretel, Ortrud in Lohengrin, Erda in Das Rheingold and Siegfried, Fricka in Die Walküre and Waltraute in Götterdämmerung. In 1927 she sang with the Los Angeles Grand Opera, appearing as Amneris as well as Giovanna in Rigoletto and Suzuki in Madama Butterfly.