In 2012, Isabelle starred in the popular horror film American Mary, which earned her special mention at the Austin Fantastic Fest, Festival Trophy Award for Best Actress, Special Award for Best Actress, Fright Meter Award for Best Actress, and Fangoria Chainsaw Award for Best Leading Actress. More recently she has appeared in 13 Eerie (2013), Torment (2013), and Laurence & Holloman (2013) which earned her a Leo Award nomination for Best Supporting Performance by a Female in a Motion Picture. In 2014, she starred in See No Evil 2.