In the early 1990s, McNeil was a cast member of two television shows, WIOU and Bodies of Evidence. Kate McNeil has also made numerous television guest appearances. She has appeared on Amazing Stories, Simon & Simon, Designing Women, Midnight Caller, Quantum Leap, The X-Files, Murder, She Wrote, Babylon 5, Diagnosis Murder, Veronica Mars, Bones, The Mentalist, and Mad Men.