After Grange Hill, Clarke filmed Popcorn with Jodi Albert and Jack Ryder, and plays the character of Yukino. She has also appeared in the Sky1 football drama Dream Team. Other roles include Zoe Stringer in Filthy Rich, in which she played Mike Reid's daughter shortly before he died, The Bill, where she played Chloe Fox for 3 episodes in 2004 and appeared again in October 2007 as Kelly Burgess, and Casualty in which she appeared as Claudie Waters for 2 episodes on 29 and 30 December 2007. In 2008, Clarke was the face of Clean & Clear, appearing in adverts for the skincare brand. She also starred in the Road Safety commercial 'Mess'. In 2008 she became Galaxy chocolate's 'Miss Kiss' to publicize their Christmas Mistletoe Kisses chocolates. In 2009 and 2010 she appeared in the E4 sitcom The Inbetweeners, as Neil's sister Katie in the series 2 episode "A Night Out in London" and series 3's "Will's Dilemma".