After being recognized as an accomplished session player, Brion branched out into production on then-girlfriend Mann's 1993 solo debut, Whatever, and its follow-up, I'm With Stupid. He has also produced albums by Fiona Apple, Rufus Wainwright, Eleni Mandell, Rhett Miller, Robyn Hitchcock, Brad Mehldau and Evan Dando, and co-produced Kanye West's Late Registration in 2005.