In 1935, McIntire married Actress Jeanette Nolan, and the couple had two children together, one of whom was the actor Tim McIntire (1944–1986) who starred in the 1978 film American Hot Wax. Their daughter Holly was also an Actress, appearing in two episodes of Wagon Train. McIntire and Nolan both appeared in Psycho. He played a sheriff, while she voiced some of the "mother" lines. In the Wagon Train episode "The Janet Hale Story" McIntire and Nolan played husband and wife Chris and Janet Hale. In The Virginian, they also played husband and wife. They both appeared again as husband and wife in The Fugitive (1966) season 3, episode 24, as farm workers with their real life son, Tim. In the 1984 comic spy adventure Cloak & Dagger, they again played a couple. This time they portrayed sinister spies posing as harmless elderly tourists.