General research in antibodies, agglutination, and anemia continued in the years following this 1958 paper. In 1962, Dausset published an examination of the correlation between leuco-agglutination and skin graft tolerance, his first observation of the antigens’ impact on histocompatibility. His next paper on the subject was published in 1964, when he observed a clear relationship between leucocyte antigen compatibility and antibody response to skin grafts. This finding sparked a flurry of research in the topic of histocompatibility, and by the end of 1965 Dausset had published over a dozen papers exploring leucocyte antigens and their relevance to histocompatibility. After identifying that a two-allele leucocyte antigen group had an influence on histocompatibility and observing the induction of hyper-sensitivity to skin grafts following injection of leucocyte fractions, Dausset developed a system for grouping leucocyte antigens on the basis of histocompatibility. Following this, he put forth the hypothesis that all known leucocyte antigens were part of a single complex, a complex which he named Hu-1. This complex would later become known as one of the Major Histocompatibility Complexes (MHC), specifically those termed Human Leucocyte Antigens (HLA). Dausset’s further work in 1965 examining the effects of Hu-1 antigen injection on skin graft rejection further confirmed the conclusion that this Hu-1 complex was indeed a transplantation antigen, a conclusion which would in time have profound effects on the transplantation process.