Uggie's earliest roles were in commercials and minor roles in the films What's Up Scarlett, Wassup Rockers (2005) and Mr. Fix It (2006) alongside David Boreanaz. His first named role, and big break, was as "Queenie" in the romantic drama Water for Elephants, alongside actors Robert Pattinson and Reese Witherspoon. He appeared in "The Incredible Dog Show" from August 2010 onwards, a tour of dogs with different tricks, which toured the United States and South America; his trick was riding a skateboard.