Plana has acted in films such as An Officer and a Gentleman, Three Amigos!, Goal!, Lone Star, and others. He is known to PC gamers as the voice of Manny Calavera in the LucasArts 1998 adventure game Grim Fandango. In 2011, Plana guest starred in Desperate Housewives as Gabrielle Solis's abusive stepfather, Alejandro Perez. He also directed Witch's Lament, a Desperate Housewives episode in the show's eighth season. In 2011, he appeared in Body of Proof, in the episode "Helping Hand".