Lifford graduated from the University of Santa Monica. She began her career in 1980s, appearing on television shows include Hill Street Blues, Cagney & Lacey, and Murder, She Wrote. From 1983 to 1988, she had the recurring role on Knots Landing. In film, she made her debut in The Ladies Club (1986). The following years, she had appeared in films include Nuts (1987), Colors (1988), Paris Trout (1991), Grand Canyon (1991), Letters from a Killer (1998), Panic (2000), Pay It Forward (2000), Joe Somebody (2001), Blood Work (2002), Hostage (2005), and Catch and Release (2006).