Essman began her acting career with small parts in two 1988 films – Crocodile Dundee II and Punchline – but is best known for her role as Susie Greene, the wife of Jeff Greene (portrayed by Jeff Garlin), on the HBO comedy series Curb Your Enthusiasm. Essman told The New York Times that, by the show's third season, she could not "walk down the street anymore without people stopping her and begging her to say [her character's catchphrase] 'You fat fuck'". In 2007, Slate named Essman's character one of the best on television, and a reason the publication looked forward to the return of the show.