In 2001, he took the lead in BBC Two sitcom World of Pub, playing the same character as he had done in the show's run on Radio 4. He appeared in The Junkies, an Internet sitcom. In 2002, the critically acclaimed Look Around You, a series of 10-minute 1970s school science video spoofs, debuted on BBC Two in which he played a scientist. He co-wrote the show alongside Robert Popper, whom he met on the set of Spaced. The show returned in 2005 as a spoof of the 1980s show Tomorrow's World, with Serafinowicz playing Peter Packard, one of the presenters.