After a starring of small roles in television and film, Griffin landed a recurring guest-starring role on Fox's The O.C., in 2005, and then briefly in 2006. On The O.C. Griffin played party girl and drug addict Jess Sathers, also known as 'Floater Girl'. In the summer of 2005, she played Katie-Lynn Johnson in The Dukes of Hazzard, as the sexy college girl that caught the eye of cousins Bo and Luke Duke.