Lee is married to animation Producer and comic book author Paul Dini, with whom she lives in Los Angeles. Their two Boston terriers, Mugsy and Deuce, were featured in "Anger Management", a 2012 episode of The Dog Whisperer, in which they sought Cesar Millan's help with their dogs' behavioral problems. Around this time, Dini began an extensive weight loss and exercise regimen, having reached a weight of 320 pounds.