In 1990, she appeared in two films of Mahesh Bhatt, first Awaargi, an art house film. Meenakshi's performance was critically acclaimed and many critics call it her best performance, the second film was Jurm, released in the same year. The film was a critical and commercial success. Her role of a wife who has to face problems after her husband gets involved with another woman gained immense critical praise. She received her first nomination for the Filmfare Award for best Actress for her role in the film. She also appeared in the woman-centric film Ghar Ho To Aisa opposite Anil Kapoor, the film was a hit and Seshadri was noted for her comic timing in the film. She then appeared in Ghayal alongside Sunny Deol. This film started her long association with Rajkumar Santoshi. Ghayal was the highest-grossing film of the 1990s and became a blockbuster upon its release. In 1991, she appeared in Akayla, directed by Ramesh Sippy, opposite Amitabh Bachchan, despite being overly hyped, the film flopped at the box office. Her on-screen pairing with Vinod Khanna was widely appreciated, and the pair gave successful films such as Satyamev Jayate, Mahaadev, Jurm, Humshakal and Police Aur Mujrim. She acted in the family drama Ghar Parivar in 1991, with Rajesh Khanna and Rishi Kapoor as her co-stars and the film did very good Business. She made her Telugu film debut with Brahmarishi Vishwamitra in 1991. In 1992, she appeared in the Telugu film Aapad Bandhavudu opposite Cheeranjeevi. In 1992 her film Aaj Ka Goonda Raaj opposite Cheeranjeevi was hit. In 1993, she appeared in the woman-centric film Damini – Lightning. Directed by filmmaker Rajkumar Santoshi, it also starred Rishi Kapoor, Sunny Deol, Amrish Puri, Tinnu Anand, and Paresh Rawal. The film was based on the sensitive subject of injustice towards a rape victim. Damini received a number of awards, including a National Film Award. She was nominated for a Filmfare Award for her role in the film Damini. Her portrayal as Damini was highly praised and she won many accolades for her performance in the film. Damini is regarded as Seshadri's career-defining role.