She made her film debut with a supporting role in the 1979 drama Boulevard Nights, which also featured John Fiedler in the cast. She followed this with roles in the films Dead Badge (1995, with Raymond Cruz, Leland Orser, and James B. Sikking) and Black Out (1996, opposite Brad Dourif, Brad Greenquist, and Jeremy Roberts). DuBois also appeared in the television movies about Princess of Monaco, Grace Kelly, opposite Salome Jens and william Schallert, and The Trial of the Incredible Hulk, with John Rhys-Davies.