In 1989–90, she had a co-starring role on the 21 Jump Street spin-off, Booker, which starred Richard Grieco in the title role. She guest starred on the detective series Murder, She Wrote in 1996. Strassman had movie roles as the wife of Rick Moranis' scientist character in Honey, I Shrunk the Kids (1989) and Honey, I Blew Up the Kid (1992). In 1994, she reprised her role from those movies in the 3-D film spin-off Honey, I Shrunk the Audience!. She later went on to play Nancy Sterngood on the television series Tremors (2003).