Lombardi was born in The Bronx, New York City, the son of Louis Lombardi, Sr. On television, Lombardi had a recurring role on The Sopranos as Agent Skip Lipari, and guest starred on such shows as Entourage, Heroes and CSI. He was a cast member of a 1990s revival of Fantasy Island and played Edgar Stiles on 24. He also played Stucky Fein in the short-lived television show Mob City.