She appeared in feature films such as Forgetting Sarah Marshall and I Love You, Man. She also co-starred as "Byte" in the Adult Swim series Fat Guy Stuck in Internet in 2008 and also starred as a housewife in another series called "Infomercials" in 2014. In early 2009, Cackowski wrote for the short-lived ABC sitcom In the Motherhood. From 2009 to 2010, she worked as a Writer and story Editor on the NBC comedy series Community. Her brother is Comedian Craig Cackowski, who has also appeared with guest roles on Community. She also wrote for the short lived NBC sitcom Up All Night. She wrote 2 episodes of 2015 comedy The Last Man on Earth on Fox.