In the early afternoon of October 10, 2004, Caminiti was in the apartment of his friend in The Bronx, New York City, after being in the bathroom to have a speedball of cocaine and heroin, Caminiti came out and collapsed on the floor. At 3:36 pm a 911 call was made while Caminiti was going into cardiac arrest. Caminiti died at Lincoln Hospital in The Bronx at 6:45 pm. Preliminary news reports indicated he died of a heart attack, but the autopsy results stated that "acute intoxication due to the combined effects of cocaine and opiates" caused his death, with coronary artery disease and cardiac hypertrophy (an enlarged heart) as contributing factors. Media coverage of Caminiti's death was almost completely overshadowed by that of actor Christopher Reeve, who also died in New York City the same day as Caminiti.