Keane received her Bachelor of Fine Arts from Emporia State University in 1996 and a M.F.A. with honors from California State University, Long Beach. In addition to a number of theatrical credits (including performances as Lady Macbeth and Desdemona), she is best known for her role as Audie Gallagher in the television series Ruby & the Rockits. She has also had guest appearances on Passions, Strong Medicine, CSI: NY, How I Met Your Mother, NCIS, Without a Trace, and Eli Stone. She portrays Sarah in the 2010 Bollywood film My Name Is Khan.