Greer had recurring role on the Fox comedy series Arrested Development (2003–2005, 2013), playing Kitty Sanchez in 10 episodes total and appearing in each of the series' three original seasons. In an August 2009 interview, Greer said that she is most recognized for this role. She had supporting roles in Jawbreaker (1999), What Women Want (2000), The Wedding Planner (2001), Adaptation (2002), 13 Going on 30 (2004), The Village (2004), Elizabethtown (2005), 27 Dresses (2008), and Love Happens (2009). Greer has made guest appearances on Just Shoot Me! (2003), CSI: Miami (2005), My Name Is Earl (2006), It's Always Sunny in Philadelphia (2007, 2011), Californication (2007–2008, 2012), ER (2009), House (2009), Modern Family (2010), The Big Bang Theory (2010), How I Met Your Mother (2010) and Warren the Ape (2010). She took on a starring role in the ABC sitcom Miss Guided (2008), but it was canceled in its first season. She also starred in the indie satire Visioneers (2008).