Capodice was born in Chicago, Illinois. He began his film and television career in the late 1970s. His first role was in the ABC-TV soap opera Ryan's Hope, where he appeared in six episodes as Lloyd Lord. He had guest roles on numerous other TV series, including Spenser: For Hire, Kate & Allie, Murphy Brown, Knots Landing, Hunter, and Law & Order. He appeared on the series Moonlighting in 1989 and performed as a guest star in an episode of NBC-TV's Will & Grace (episode 1.19), in the role of the plumber who suffers a heart attack.