His first Tamil was Madrasi, and in 2012, he appeared as the antagonist in Tamil film Thaandavam. Subsequently, he played the lead role in Jai Bolo Telangana, which won five Nandi Awards. In 2012, he debuted in the Kannada film Bachchan as a cop, which featured Sudeep in the lead role. In 2013, Jagapati Babu returned to the Tamil film industry with Puthagam and will next be seen in Rudhiram. Jagapati Babu is now doing a Malayalam film Pulimurugan with National Award winner Mohanlal. His next movie was Legend in 2014 where he played the antagonist against Nandamuri Balakrishna. In the same year, he acted as villain opposite Rajinikanth in Lingaa. In 2015, he played Mahesh Babu's father in Srimanthudu. In 2016, he played an antagonist in Jr. NTR's Nannaku Prematho He played antagonist in Ism and Jaguar He played villain opposite Vijay in Bairava and also villain opposite Mohanlal in Pulimurgan. In 2017, he played Naga Chaitanya's father in Rarandoi Veduka Chudham. He recently played a lead role in the movie Patel S. I. R. He also has an important role in Ram Charan's Rangasthalam.