Frank Pando was born in Valparaíso, Chile, to Francisco Pando and Marta Gómez. When his family moved to the United States, he started his acting career. He distinguished himself as playing the character Agent Frank Grasso in the Television series The Sopranos. Pando also portrayed Pablo in the 2005 version of A Streetcar Named Desire, from Studio 54, and provided a voiceover for a male Cowboy in Red Dead Redemption. He has also acted in many other roles in several TV shows, and along with fellow actor Armando Riesco and his wife Shirley Rumierk, has a collaborative YouTube channel called "Rumando Pando". In 2016, he was cast in a main role in the Lynne Ramsay film You Were Never Really Here, and he was also cast in a starring role in a San Diego production of the play The Blameless.