Nenninger has starred in two films, Jeepers Creepers 2 and The Pool at Maddy Breaker's, and appeared in several TV series, including The X-Files, NCIS, CSI: Crime Scene Investigation, Generation Kill, and Malcolm in the Middle. He has a supporting role on the TV series Glory Daze. In 2011, Nenninger co-starred as the voice and likeness of Matthew Ryan in the video game L.A. Noire.