De Matteo played the stepmother of Steve Wilde, the main character of the FOX comedy Running Wilde, appearing in Season 1, Episode 9. De Matteo co-starred as Krissi Cates in the film adaptation of Dark Places (2015), with Charlize Theron, Chloë Grace Moretz, and Nicholas Hoult. In 2015, she was cast as Det. Tess Nazario in the NBC drama series Shades of Blue, starring alongside Jennifer Lopez and Ray Liotta. It premiered on January 7, 2016.