For several seasons, Fowley played the key supporting role of John H. "Doc" Holliday in the 1955-1961 western television series The Life and Legend of Wyatt Earp after having appeared as Doc Fabrique in the show's premiere season. This role allowed Fowley to demonstrate his flair for comedy and other acting skills as a clever, sharp-witted, sardonic, cynical, alcoholic, poker-playing foil to the square-jawed, milk-drinking, church-going Wyatt Earp (Hugh O'Brian), whom Holiday nicknamed "Deacon" due to his rigid sense of morality. Not at all so encumbered Doc would occasionally take the law into his own hands behind Earp's back to protect his friend from legal action or even death when the marshal was legally or morally ham-strung. Holliday, as played by Fowley, having no Problem working around morals or the law, could be either hilarious or cold-blooded.