Caspe's ABC series Happy Endings ran for three seasons, ending its run on May 3, 2013. As well as creating the series, he was also the executive Producer and co-showrunner. He went on to create the NBC sitcom Marry Me, which he again collaborated on with his wife Casey Wilson (they had previously met on Happy Endings), the premise was loosely based on Wilson and Caspe's relationship. The series starred Wilson and Ken Marino as a newly engaged couple and ran for one season from 2014 to 2015. Caspe is known to set his shows in his hometown of Chicago.